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Molecules 3-HBL

3-HBL Characteristics of the work

Selected as one of the Top 10 Molecules from Biomass by the DOE, 3-HBL could be a key intermediate in the production of variety of products in the pharmeceutical industry. Our ability to cheaply specify the chirality offers a huge competitive advangtageLong range it has a potential as a fiber as well.

  • Chiral specificity
  • Statin Production
  • Anti-infectives
  • Fibers
  • Pure Left or Right
  • Atorvastatin and others
  • Oxazolidinone
  • Amino Analogs to lycra

The Challenge

Within nature chiral specificity is incredibly important. Using traditional chemistry separating the two versions is very expensive. The pharmaceutical industry is challenged daily to lower its costs to produce the correct version especially within statins such as atorvastin (generic name of Lipitor) or simvastatin (generic name of Crestor).

A similar problem exists for the emerging Oxazolidinone class of antibiotics. Oxazolidinones are a promising new opportunity to offer new treatments but the production costs remain very high.

The Solution

By creating a new pathway within microorganisms, you are able to leverage nature's nature affinity for different chircality. Fermentation then offers a low cost, well understood approach to scaling to deliver very high e.e. intermediates along with lower cost production. This is important to branded pharmaceuticals as their product loses patent protection and of course the generic industry.

3-HBL offers the core structure along with the chirality needed for this exciting new and emerging class of antibiotics. Our 3-HBL offers a simplified direct production method with high purity and lower costs.

Products Clean, Green Molecules